USLC 2021
879 players with recorded stats, 509 games.
Games
| Wk | Matchup | Score | Result | Date | Players |
|---|---|---|---|---|---|
| — | |||||
| — | Louisville @ Tampa Bay | 2–3 | Tampa Bay win | 2021-11-21 | 0 |
| — | San Antonio @ Orange County | 1–1 | Draw | 2021-11-21 | 0 |
| — | Orange County @ Tampa Bay | 3–1 | Orange County win | 2021-11-29 | 0 |
| Week 1 | |||||
| 1 | Atlanta @ Louisville | 0–2 | Louisville win | 2021-04-24 | 0 |
| 1 | Tulsa @ Oklahoma City | 3–1 | Tulsa win | 2021-04-25 | 0 |
| Week 2 | |||||
| 2 | Hartford @ New York | 3–2 | Hartford win | 2021-04-30 | 0 |
| 2 | Charlotte @ Tampa Bay | 0–3 | Tampa Bay win | 2021-05-01 | 0 |
| 2 | Indy @ Birmingham | 1–0 | Indy win | 2021-05-01 | 0 |
| 2 | Sacramento @ Ventura County | 1–0 | Sacramento win | 2021-05-01 | 0 |
| 2 | San Diego @ Phoenix | 1–4 | Phoenix win | 2021-05-01 | 0 |
| 2 | Colorado Springs @ San Antonio | 0–3 | San Antonio win | 2021-05-02 | 0 |
| 2 | New Mexico @ Rio Grande Valley | 0–1 | Rio Grande Valley win | 2021-05-02 | 0 |
| 2 | Kansas City @ Tulsa | 0–2 | Tulsa win | 2021-05-02 | 0 |
| Week 3 | |||||
| 3 | Atlanta @ Oklahoma City | 1–0 | Atlanta win | 2021-05-02 | 0 |
| 3 | Loudoun @ Miami | 1–2 | Miami win | 2021-05-02 | 0 |
| 3 | Oklahoma City @ Kansas City | 1–1 | Draw | 2021-05-08 | 0 |
| 3 | Tulsa @ Indy | 2–0 | Tulsa win | 2021-05-08 | 0 |
| 3 | New Mexico @ El Paso | 1–1 | Draw | 2021-05-09 | 0 |
| Week 4 | |||||
| 4 | Las Vegas @ Ventura County | 0–5 | Ventura County win | 2021-05-06 | 0 |
| 4 | San Diego @ Rio Grande Valley | 0–1 | Rio Grande Valley win | 2021-05-07 | 0 |
| 4 | Las Vegas @ Sacramento | 1–3 | Sacramento win | 2021-05-13 | 0 |
| 4 | Charlotte @ Charleston | 3–0 | Charlotte win | 2021-05-14 | 0 |
| 4 | San Diego @ Tacoma | 1–3 | Tacoma win | 2021-05-14 | 0 |
| 4 | Pittsburgh @ Hartford | 1–1 | Draw | 2021-05-15 | 0 |
| 4 | Ventura County @ Real Monarchs | 2–0 | Ventura County win | 2021-05-15 | 0 |
| 4 | Austin @ New Mexico | 1–3 | New Mexico win | 2021-05-16 | 0 |
| Week 5 | |||||
| 5 | Charleston @ New York | 1–1 | Draw | 2021-05-07 | 0 |
| 5 | Birmingham @ Louisville | 1–1 | Draw | 2021-05-08 | 0 |
| 5 | Hartford @ Miami | 1–0 | Hartford win | 2021-05-08 | 0 |
| 5 | Pittsburgh @ Tampa Bay | 0–3 | Tampa Bay win | 2021-05-08 | 0 |
| 5 | Oakland @ Phoenix | 0–3 | Phoenix win | 2021-05-09 | 0 |
| 5 | Real Monarchs @ San Antonio | 2–2 | Draw | 2021-05-09 | 0 |
| 5 | Tacoma @ Ventura County | 1–1 | Draw | 2021-05-10 | 0 |
| 5 | New York @ Loudoun | 2–1 | New York win | 2021-05-18 | 0 |
| 5 | Tulsa @ Atlanta | 0–5 | Atlanta win | 2021-05-19 | 0 |
| 5 | New Mexico @ Colorado Springs | 3–1 | New Mexico win | 2021-05-22 | 0 |
| 5 | Sacramento @ Orange County | 0–1 | Orange County win | 2021-05-23 | 0 |
| Week 6 | |||||
| 6 | Las Vegas @ San Diego | 1–2 | San Diego win | 2021-05-30 | 0 |
| 6 | Tacoma @ Austin | 0–1 | Austin win | 2021-10-07 | 0 |
| Week 7 | |||||
| 7 | Miami @ New York | 1–0 | Miami win | 2021-05-14 | 0 |
| 7 | Colorado Springs @ Kansas City | 4–0 | Colorado Springs win | 2021-05-15 | 0 |
| 7 | Memphis @ Birmingham | 0–1 | Birmingham win | 2021-05-15 | 0 |
| 7 | Atlanta @ Oklahoma City | 2–2 | Draw | 2021-05-16 | 0 |
| 7 | Orange County @ Tacoma | 0–1 | Tacoma win | 2021-05-16 | 0 |
| 7 | Phoenix @ Tampa Bay | 1–2 | Tampa Bay win | 2021-05-16 | 0 |
| 7 | San Antonio @ Rio Grande Valley | 1–2 | Rio Grande Valley win | 2021-05-17 | 0 |
| 7 | Tampa Bay @ Charlotte | 0–1 | Charlotte win | 2021-06-05 | 0 |
| 7 | Austin @ Pittsburgh | 1–0 | Austin win | 2021-06-06 | 0 |
| 7 | Tacoma @ Las Vegas | 0–2 | Las Vegas win | 2021-06-06 | 0 |
| Week 8 | |||||
| 8 | Kansas City @ Ventura County | 1–1 | Draw | 2021-05-20 | 0 |
| Week 9 | |||||
| 9 | Austin @ Real Monarchs | 1–1 | Draw | 2021-05-22 | 0 |
| 9 | Charlotte @ Pittsburgh | 1–0 | Charlotte win | 2021-05-22 | 0 |
| 9 | Miami @ Tampa Bay | 1–2 | Tampa Bay win | 2021-05-22 | 0 |
| 9 | San Diego @ Louisville | 1–2 | Louisville win | 2021-05-22 | 0 |
| 9 | Kansas City @ Indy | 0–2 | Indy win | 2021-05-22 | 0 |
| 9 | Birmingham @ San Antonio | 1–2 | San Antonio win | 2021-05-23 | 0 |
| 9 | Las Vegas @ Phoenix | 1–5 | Phoenix win | 2021-05-23 | 0 |
| 9 | Memphis @ Atlanta | 2–2 | Draw | 2021-05-23 | 0 |
| 9 | New York @ Charleston | 2–2 | Draw | 2021-05-23 | 0 |
| 9 | Rio Grande Valley @ El Paso | 0–1 | El Paso win | 2021-05-23 | 0 |
| 9 | Oakland @ Ventura County | 3–2 | Oakland win | 2021-05-24 | 0 |
| 9 | Atlanta @ Memphis | 0–1 | Memphis win | 2021-06-17 | 0 |
| 9 | Sacramento @ Oakland | 0–0 | Draw | 2021-08-12 | 0 |
| Week 10 | |||||
| 10 | Oklahoma City @ Birmingham | 0–1 | Birmingham win | 2021-05-27 | 0 |
| 10 | Real Monarchs @ Austin | 0–2 | Austin win | 2021-05-27 | 0 |
| Week 11 | |||||
| 11 | Pittsburgh @ New York | 3–0 | Pittsburgh win | 2021-05-28 | 0 |
| 11 | Charlotte @ Miami | 1–2 | Miami win | 2021-05-29 | 0 |
| 11 | Indy @ Louisville | 2–1 | Indy win | 2021-05-29 | 0 |
| 11 | Birmingham @ Atlanta | 1–0 | Birmingham win | 2021-05-30 | 0 |
| 11 | El Paso @ Kansas City | 0–0 | Draw | 2021-05-30 | 0 |
| 11 | Loudoun @ New Mexico | 1–0 | Loudoun win | 2021-05-30 | 0 |
| 11 | Memphis @ Oklahoma City | 0–0 | Draw | 2021-05-30 | 0 |
| 11 | Phoenix @ Sacramento | 1–0 | Phoenix win | 2021-05-30 | 0 |
| 11 | Rio Grande Valley @ San Antonio | 1–1 | Draw | 2021-05-30 | 0 |
| 11 | Real Monarchs @ Hartford | 0–2 | Hartford win | 2021-09-15 | 0 |
| Week 12 | |||||
| 12 | Oklahoma City @ Indy | 1–1 | Draw | 2021-06-02 | 0 |
| 12 | Pittsburgh @ Loudoun | 3–2 | Pittsburgh win | 2021-06-02 | 0 |
| 12 | Tampa Bay @ New York | 1–0 | Tampa Bay win | 2021-06-02 | 0 |
| 12 | Oakland @ Sacramento | 3–3 | Draw | 2021-06-03 | 0 |
| 12 | Tulsa @ Kansas City | 1–4 | Kansas City win | 2021-06-03 | 0 |
| 12 | El Paso @ Austin | 1–0 | El Paso win | 2021-06-04 | 0 |
| Week 13 | |||||
| 13 | Memphis @ Indy | 2–1 | Memphis win | 2021-06-05 | 0 |
| 13 | New Mexico @ Real Monarchs | 1–0 | New Mexico win | 2021-06-05 | 0 |
| 13 | New York @ Hartford | 0–7 | Hartford win | 2021-06-05 | 0 |
| 13 | Louisville @ Atlanta | 0–1 | Atlanta win | 2021-06-06 | 0 |
| 13 | Orange County @ Sacramento | 3–1 | Orange County win | 2021-06-06 | 0 |
| 13 | Rio Grande Valley @ Miami | 4–2 | Rio Grande Valley win | 2021-06-06 | 0 |
| 13 | San Antonio @ Colorado Springs | 1–1 | Draw | 2021-06-06 | 0 |
| 13 | San Diego @ Phoenix | 2–2 | Draw | 2021-06-06 | 0 |
| 13 | Tulsa @ Birmingham | 1–2 | Birmingham win | 2021-06-06 | 0 |
| 13 | Ventura County @ Charleston | 1–3 | Charleston win | 2021-10-20 | 0 |
| Week 14 | |||||
| 14 | Charleston @ Loudoun | 1–0 | Charleston win | 2021-06-08 | 0 |
| 14 | Kansas City @ Atlanta | 2–2 | Draw | 2021-06-09 | 0 |
| 14 | Indy @ El Paso | 0–2 | El Paso win | 2021-06-10 | 0 |
| 14 | San Diego @ Orange County | 1–1 | Draw | 2021-06-10 | 0 |
| Week 15 | |||||
| 15 | Sacramento @ Real Monarchs | 0–2 | Real Monarchs win | 2021-06-10 | 0 |
| 15 | Loudoun @ Tampa Bay | 1–2 | Tampa Bay win | 2021-06-11 | 0 |
| 15 | Memphis @ Louisville | 0–3 | Louisville win | 2021-06-12 | 0 |
| 15 | Miami @ Pittsburgh | 1–1 | Draw | 2021-06-12 | 0 |
| 15 | San Antonio @ Las Vegas | 1–1 | Draw | 2021-06-12 | 0 |
| 15 | Austin @ New Mexico | 0–0 | Draw | 2021-06-13 | 0 |
| 15 | Birmingham @ Oklahoma City | 2–1 | Birmingham win | 2021-06-13 | 0 |
| 15 | Colorado Springs @ El Paso | 1–1 | Draw | 2021-06-13 | 0 |
| 15 | Hartford @ Charlotte | 2–3 | Charlotte win | 2021-06-13 | 0 |
| 15 | Oakland @ Orange County | 0–1 | Orange County win | 2021-06-13 | 0 |
| 15 | Real Monarchs @ Rio Grande Valley | 0–1 | Rio Grande Valley win | 2021-06-13 | 0 |
| 15 | Tacoma @ Phoenix | 0–3 | Phoenix win | 2021-06-13 | 0 |
| 15 | Ventura County @ San Diego | 1–2 | San Diego win | 2021-06-13 | 0 |
| 15 | Pittsburgh @ Indy | 1–0 | Pittsburgh win | 2021-06-16 | 0 |
| 15 | New York @ Charleston | 3–2 | New York win | 2021-09-22 | 0 |
| Week 16 | |||||
| 16 | Birmingham @ Louisville | 0–2 | Louisville win | 2021-06-16 | 0 |
| 16 | Charlotte @ New York | 1–3 | New York win | 2021-06-17 | 0 |
| 16 | Las Vegas @ Ventura County | 4–3 | Las Vegas win | 2021-06-17 | 0 |
| 16 | San Antonio @ New Mexico | 0–2 | New Mexico win | 2021-06-17 | 0 |
| 16 | Kansas City @ Tulsa | 3–4 | Tulsa win | 2021-06-17 | 0 |
| 16 | Tacoma @ Colorado Springs | 2–4 | Colorado Springs win | 2021-06-17 | 0 |
| Week 17 | |||||
| 17 | Miami @ Charleston | 1–2 | Charleston win | 2021-06-18 | 0 |
| 17 | El Paso @ Real Monarchs | 2–1 | El Paso win | 2021-06-19 | 0 |
| 17 | Loudoun @ Hartford | 1–2 | Hartford win | 2021-06-19 | 0 |
| 17 | Pittsburgh @ Tampa Bay | 2–1 | Pittsburgh win | 2021-06-19 | 0 |
| 17 | Indy @ Kansas City | 2–1 | Indy win | 2021-06-20 | 0 |
| 17 | Louisville @ Tulsa | 3–2 | Louisville win | 2021-06-20 | 0 |
| 17 | Orange County @ Las Vegas | 3–1 | Orange County win | 2021-06-20 | 0 |
| 17 | Oklahoma City @ Memphis | 1–0 | Oklahoma City win | 2021-06-20 | 0 |
| 17 | Phoenix @ San Diego | 1–2 | San Diego win | 2021-06-20 | 0 |
| 17 | Rio Grande Valley @ San Antonio | 1–1 | Draw | 2021-06-20 | 0 |
| 17 | Austin @ Birmingham | 1–3 | Birmingham win | 2021-10-14 | 0 |
| Week 18 | |||||
| 18 | Austin @ Rio Grande Valley | 2–1 | Austin win | 2021-06-17 | 0 |
| 18 | Charleston @ Charlotte | 0–3 | Charlotte win | 2021-06-23 | 0 |
| 18 | Colorado Springs @ Austin | 3–2 | Colorado Springs win | 2021-06-23 | 0 |
| 18 | Birmingham @ Miami | 1–0 | Birmingham win | 2021-06-24 | 0 |
| 18 | Orange County @ Ventura County | 1–1 | Draw | 2021-06-24 | 0 |
| 18 | Kansas City @ Oklahoma City | 0–1 | Oklahoma City win | 2021-06-24 | 0 |
| 18 | Real Monarchs @ Tacoma | 1–1 | Draw | 2021-06-24 | 0 |
| Week 19 | |||||
| 19 | New York @ Pittsburgh | 1–2 | Pittsburgh win | 2021-06-25 | 0 |
| 19 | Charlotte @ Miami | 1–2 | Miami win | 2021-06-26 | 0 |
| 19 | Indy @ Louisville | 3–3 | Draw | 2021-06-26 | 0 |
| 19 | Loudoun @ Charleston | 0–3 | Charleston win | 2021-06-26 | 0 |
| 19 | New Mexico @ Colorado Springs | 1–3 | Colorado Springs win | 2021-06-26 | 0 |
| 19 | San Diego @ Las Vegas | 2–1 | San Diego win | 2021-06-26 | 0 |
| 19 | Tampa Bay @ Hartford | 1–0 | Tampa Bay win | 2021-06-26 | 0 |
| 19 | Tulsa @ Rio Grande Valley | 2–1 | Tulsa win | 2021-06-26 | 0 |
| 19 | Austin @ Oakland | 0–0 | Draw | 2021-06-27 | 0 |
| 19 | Oklahoma City @ Atlanta | 2–1 | Oklahoma City win | 2021-06-27 | 0 |
| 19 | Phoenix @ Sacramento | 2–1 | Phoenix win | 2021-06-27 | 0 |
| 19 | San Antonio @ Real Monarchs | 1–1 | Draw | 2021-06-27 | 0 |
| 19 | Kansas City @ Memphis | 3–2 | Kansas City win | 2021-06-27 | 0 |
| 19 | Ventura County @ Tacoma | 0–2 | Tacoma win | 2021-06-27 | 0 |
| Week 20 | |||||
| 20 | Oakland @ San Diego | 0–1 | San Diego win | 2021-06-30 | 0 |
| 20 | El Paso @ Rio Grande Valley | 2–3 | Rio Grande Valley win | 2021-07-01 | 0 |
| 20 | New Mexico @ Real Monarchs | 2–3 | Real Monarchs win | 2021-07-01 | 0 |
| 20 | Pittsburgh @ Loudoun | 1–2 | Loudoun win | 2021-07-01 | 0 |
| 20 | Orange County @ Colorado Springs | 2–0 | Orange County win | 2021-07-02 | 0 |
| 20 | Atlanta @ Birmingham | 1–3 | Birmingham win | 2021-08-05 | 0 |
| Week 21 | |||||
| 21 | Charleston @ Tampa Bay | 0–1 | Tampa Bay win | 2021-07-02 | 0 |
| 21 | Miami @ New York | 1–1 | Draw | 2021-07-02 | 0 |
| 21 | Birmingham @ Indy | 1–0 | Birmingham win | 2021-07-03 | 0 |
| 21 | Charlotte @ Pittsburgh | 0–1 | Pittsburgh win | 2021-07-03 | 0 |
| 21 | Louisville @ Kansas City | 4–2 | Louisville win | 2021-07-03 | 0 |
| 21 | Memphis @ Atlanta | 2–2 | Draw | 2021-07-03 | 0 |
| 21 | Sacramento @ San Diego | 1–1 | Draw | 2021-07-03 | 0 |
| 21 | Tulsa @ Oklahoma City | 0–0 | Draw | 2021-07-03 | 0 |
| 21 | Austin @ San Antonio | 1–0 | Austin win | 2021-07-04 | 0 |
| 21 | Hartford @ Loudoun | 2–0 | Hartford win | 2021-07-04 | 0 |
| 21 | New Mexico @ El Paso | 1–2 | El Paso win | 2021-07-04 | 0 |
| 21 | Tacoma @ Las Vegas | 0–1 | Las Vegas win | 2021-07-04 | 0 |
| 21 | Ventura County @ Phoenix | 0–3 | Phoenix win | 2021-07-04 | 0 |
| 21 | Real Monarchs @ Colorado Springs | 1–3 | Colorado Springs win | 2021-07-05 | 0 |
| Week 22 | |||||
| 22 | Indy @ Atlanta | 1–1 | Draw | 2021-07-07 | 0 |
| 22 | New York @ Charlotte | 3–2 | New York win | 2021-07-07 | 0 |
| 22 | Tacoma @ Orange County | 0–0 | Draw | 2021-07-07 | 0 |
| 22 | Tampa Bay @ Miami | 1–2 | Miami win | 2021-07-07 | 0 |
| 22 | Oakland @ Sacramento | 0–0 | Draw | 2021-07-08 | 0 |
| Week 23 | |||||
| 23 | Pittsburgh @ Charleston | 1–1 | Draw | 2021-07-07 | 0 |
| 23 | Rio Grande Valley @ Austin | 1–1 | Draw | 2021-07-08 | 0 |
| 23 | Colorado Springs @ New Mexico | 1–3 | New Mexico win | 2021-07-10 | 0 |
| 23 | El Paso @ Real Monarchs | 3–1 | El Paso win | 2021-07-10 | 0 |
| 23 | Louisville @ Tulsa | 2–3 | Tulsa win | 2021-07-10 | 0 |
| 23 | Memphis @ Birmingham | 1–0 | Memphis win | 2021-07-10 | 0 |
| 23 | New York @ Hartford | 2–2 | Draw | 2021-07-10 | 0 |
| 23 | Phoenix @ Charlotte | 1–1 | Draw | 2021-07-10 | 0 |
| 23 | Kansas City @ Atlanta | 1–0 | Kansas City win | 2021-07-10 | 0 |
| 23 | Las Vegas @ Oakland | 2–1 | Las Vegas win | 2021-07-11 | 0 |
| 23 | Miami @ Loudoun | 4–1 | Miami win | 2021-07-11 | 0 |
| 23 | Orange County @ Sacramento | 2–0 | Orange County win | 2021-07-11 | 0 |
| 23 | Tacoma @ Ventura County | 1–1 | Draw | 2021-07-12 | 0 |
| 23 | Indy @ Oklahoma City | 1–1 | Draw | 2021-09-30 | 0 |
| Week 24 | |||||
| 24 | Charleston @ New Mexico | 1–2 | New Mexico win | 2021-07-13 | 0 |
| 24 | Hartford @ Tampa Bay | 1–0 | Hartford win | 2021-07-13 | 0 |
| 24 | Oklahoma City @ Louisville | 1–3 | Louisville win | 2021-07-14 | 0 |
| 24 | Orange County @ San Diego | 1–2 | San Diego win | 2021-07-15 | 0 |
| 24 | Sacramento @ Las Vegas | 2–1 | Sacramento win | 2021-07-15 | 0 |
| 24 | Phoenix @ Oakland | 1–3 | Oakland win | 2021-08-26 | 0 |
| Week 25 | |||||
| 25 | Atlanta @ Louisville | 0–2 | Louisville win | 2021-07-17 | 0 |
| 25 | Hartford @ Charleston | 1–3 | Charleston win | 2021-07-17 | 0 |
| 25 | Loudoun @ Pittsburgh | 0–1 | Pittsburgh win | 2021-07-17 | 0 |
| 25 | Memphis @ Indy | 1–1 | Draw | 2021-07-17 | 0 |
| 25 | San Antonio @ Colorado Springs | 3–2 | San Antonio win | 2021-07-17 | 0 |
| 25 | Tampa Bay @ Miami | 1–2 | Miami win | 2021-07-17 | 0 |
| 25 | Las Vegas @ El Paso | 0–1 | El Paso win | 2021-07-18 | 0 |
| 25 | Oklahoma City @ Tulsa | 2–1 | Oklahoma City win | 2021-07-18 | 0 |
| 25 | Rio Grande Valley @ Orange County | 2–0 | Rio Grande Valley win | 2021-07-18 | 0 |
| 25 | Ventura County @ Phoenix | 0–5 | Phoenix win | 2021-07-18 | 0 |
| 25 | Real Monarchs @ Austin | 0–1 | Austin win | 2021-07-19 | 0 |
| 25 | Birmingham @ Kansas City | 1–0 | Birmingham win | 2021-09-02 | 0 |
| 25 | Tacoma @ Oakland | 1–3 | Oakland win | 2021-09-16 | 0 |
| 25 | New York @ Charlotte | 1–2 | Charlotte win | 2021-10-09 | 0 |
| Week 26 | |||||
| 26 | New Mexico @ San Antonio | 0–3 | San Antonio win | 2021-07-22 | 0 |
| Week 27 | |||||
| 27 | Charlotte @ Charleston | 0–2 | Charleston win | 2021-07-23 | 0 |
| 27 | Pittsburgh @ New York | 3–1 | Pittsburgh win | 2021-07-23 | 0 |
| 27 | Birmingham @ Indy | 2–1 | Birmingham win | 2021-07-24 | 0 |
| 27 | Loudoun @ Tampa Bay | 1–3 | Tampa Bay win | 2021-07-24 | 0 |
| 27 | Louisville @ Colorado Springs | 1–1 | Draw | 2021-07-24 | 0 |
| 27 | Las Vegas @ Real Monarchs | 2–3 | Real Monarchs win | 2021-07-24 | 0 |
| 27 | Miami @ Hartford | 0–2 | Hartford win | 2021-07-24 | 0 |
| 27 | Austin @ Rio Grande Valley | 1–1 | Draw | 2021-07-25 | 0 |
| 27 | El Paso @ New Mexico | 0–0 | Draw | 2021-07-25 | 0 |
| 27 | Phoenix @ San Diego | 1–0 | Phoenix win | 2021-07-25 | 0 |
| 27 | Sacramento @ Orange County | 2–2 | Draw | 2021-07-25 | 0 |
| 27 | Kansas City @ Oklahoma City | 0–0 | Draw | 2021-07-25 | 0 |
| 27 | Tulsa @ Memphis | 0–1 | Memphis win | 2021-07-25 | 0 |
| 27 | Oakland @ Ventura County | 0–3 | Ventura County win | 2021-07-26 | 0 |
| Week 28 | |||||
| 28 | Charleston @ Loudoun | 5–3 | Charleston win | 2021-07-27 | 0 |
| 28 | Orange County @ Las Vegas | 1–3 | Las Vegas win | 2021-07-28 | 0 |
| 28 | Tulsa @ Atlanta | 1–2 | Atlanta win | 2021-07-28 | 0 |
| 28 | El Paso @ San Antonio | 2–1 | El Paso win | 2021-07-29 | 0 |
| 28 | Louisville @ Kansas City | 2–1 | Louisville win | 2021-07-29 | 0 |
| 28 | San Diego @ Tacoma | 1–2 | Tacoma win | 2021-07-30 | 0 |
| Week 29 | |||||
| 29 | Atlanta @ Birmingham | 2–2 | Draw | 2021-07-31 | 0 |
| 29 | Colorado Springs @ Loudoun | 3–1 | Colorado Springs win | 2021-07-31 | 0 |
| 29 | Hartford @ Pittsburgh | 1–3 | Pittsburgh win | 2021-07-31 | 0 |
| 29 | Oklahoma City @ Louisville | 1–2 | Louisville win | 2021-07-31 | 0 |
| 29 | Tampa Bay @ Charlotte | 0–2 | Charlotte win | 2021-07-31 | 0 |
| 29 | Charleston @ Miami | 2–3 | Miami win | 2021-08-01 | 0 |
| 29 | Memphis @ Kansas City | 2–1 | Memphis win | 2021-08-01 | 0 |
| 29 | New Mexico @ Tacoma | 0–0 | Draw | 2021-08-01 | 0 |
| 29 | New York @ Sacramento | 1–3 | Sacramento win | 2021-08-01 | 0 |
| 29 | Orange County @ Oakland | 3–0 | Orange County win | 2021-08-01 | 0 |
| 29 | Rio Grande Valley @ Phoenix | 1–3 | Phoenix win | 2021-08-01 | 0 |
| 29 | San Antonio @ Austin | 3–0 | San Antonio win | 2021-08-01 | 0 |
| 29 | Real Monarchs @ El Paso | 1–3 | El Paso win | 2021-08-01 | 0 |
| 29 | San Diego @ Ventura County | 2–0 | San Diego win | 2021-08-02 | 0 |
| Week 30 | |||||
| 30 | Miami @ Hartford | 1–1 | Draw | 2021-08-04 | 0 |
| 30 | Colorado Springs @ Austin | 1–2 | Austin win | 2021-08-05 | 0 |
| 30 | Indy @ Tulsa | 2–0 | Indy win | 2021-08-05 | 0 |
| 30 | Phoenix @ Oakland | 1–0 | Phoenix win | 2021-08-05 | 0 |
| 30 | Rio Grande Valley @ Real Monarchs | 3–0 | Rio Grande Valley win | 2021-08-05 | 0 |
| 30 | San Antonio @ El Paso | 0–2 | El Paso win | 2021-08-05 | 0 |
| 30 | Sacramento @ Tacoma | 1–1 | Draw | 2021-08-06 | 0 |
| Week 31 | |||||
| 31 | Charlotte @ Loudoun | 0–0 | Draw | 2021-08-06 | 0 |
| 31 | Pittsburgh @ Charleston | 3–2 | Pittsburgh win | 2021-08-06 | 0 |
| 31 | Tampa Bay @ New York | 2–1 | Tampa Bay win | 2021-08-06 | 0 |
| 31 | Kansas City @ Louisville | 1–4 | Louisville win | 2021-08-07 | 0 |
| 31 | Austin @ El Paso | 0–3 | El Paso win | 2021-08-08 | 0 |
| 31 | Birmingham @ Tulsa | 1–3 | Tulsa win | 2021-08-08 | 0 |
| 31 | Hartford @ Colorado Springs | 2–4 | Colorado Springs win | 2021-08-08 | 0 |
| 31 | Indy @ Atlanta | 2–6 | Atlanta win | 2021-08-08 | 0 |
| 31 | Memphis @ Oklahoma City | 1–4 | Oklahoma City win | 2021-08-08 | 0 |
| 31 | Oakland @ Tacoma | 1–3 | Tacoma win | 2021-08-08 | 0 |
| 31 | Phoenix @ Las Vegas | 2–2 | Draw | 2021-08-08 | 0 |
| 31 | Real Monarchs @ San Diego | 1–0 | Real Monarchs win | 2021-08-08 | 0 |
| 31 | Ventura County @ Orange County | 3–2 | Ventura County win | 2021-08-08 | 0 |
| 31 | San Antonio @ Rio Grande Valley | 2–1 | San Antonio win | 2021-08-09 | 0 |
| Week 32 | |||||
| 32 | Colorado Springs @ Memphis | 1–1 | Draw | 2021-08-11 | 0 |
| 32 | Miami @ Pittsburgh | 3–2 | Miami win | 2021-08-11 | 0 |
| 32 | Oklahoma City @ Atlanta | 2–2 | Draw | 2021-08-11 | 0 |
| 32 | Kansas City @ Birmingham | 2–4 | Birmingham win | 2021-08-12 | 0 |
| Week 33 | |||||
| 33 | Hartford @ Tampa Bay | 0–1 | Tampa Bay win | 2021-08-13 | 0 |
| 33 | Loudoun @ Charleston | 0–1 | Charleston win | 2021-08-13 | 0 |
| 33 | Atlanta @ Kansas City | 4–1 | Atlanta win | 2021-08-14 | 0 |
| 33 | Oklahoma City @ Indy | 1–2 | Indy win | 2021-08-14 | 0 |
| 33 | Pittsburgh @ Charlotte | 0–1 | Charlotte win | 2021-08-14 | 0 |
| 33 | Tulsa @ Louisville | 1–2 | Louisville win | 2021-08-14 | 0 |
| 33 | Ventura County @ Oakland | 1–2 | Oakland win | 2021-08-14 | 0 |
| 33 | Birmingham @ Memphis | 1–1 | Draw | 2021-08-15 | 0 |
| 33 | Colorado Springs @ Rio Grande Valley | 5–2 | Colorado Springs win | 2021-08-15 | 0 |
| 33 | El Paso @ New Mexico | 1–1 | Draw | 2021-08-15 | 0 |
| 33 | Las Vegas @ Sacramento | 1–2 | Sacramento win | 2021-08-15 | 0 |
| 33 | Miami @ Austin | 0–0 | Draw | 2021-08-15 | 0 |
| 33 | Orange County @ Phoenix | 1–1 | Draw | 2021-08-15 | 0 |
| 33 | Tacoma @ San Diego | 2–1 | Tacoma win | 2021-08-15 | 0 |
| 33 | San Antonio @ New York | 2–1 | San Antonio win | 2021-09-15 | 0 |
| Week 34 | |||||
| 34 | Charleston @ Hartford | 1–2 | Hartford win | 2021-08-17 | 0 |
| 34 | Indy @ Loudoun | 1–4 | Loudoun win | 2021-08-18 | 0 |
| 34 | Rio Grande Valley @ Austin | 1–1 | Draw | 2021-08-18 | 0 |
| 34 | Tampa Bay @ Pittsburgh | 0–0 | Draw | 2021-08-18 | 0 |
| 34 | Las Vegas @ San Diego | 1–5 | San Diego win | 2021-08-19 | 0 |
| 34 | Oakland @ New Mexico | 1–1 | Draw | 2021-08-19 | 0 |
| 34 | Tacoma @ Orange County | 3–0 | Tacoma win | 2021-08-19 | 0 |
| Week 35 | |||||
| 35 | Charleston @ New York | 3–2 | Charleston win | 2021-08-20 | 0 |
| 35 | Colorado Springs @ Charlotte | 3–3 | Draw | 2021-08-21 | 0 |
| 35 | Atlanta @ Pittsburgh | 1–4 | Pittsburgh win | 2021-08-22 | 0 |
| 35 | Hartford @ Miami | 0–2 | Miami win | 2021-08-22 | 0 |
| 35 | Indy @ Kansas City | 1–1 | Draw | 2021-08-22 | 0 |
| 35 | Louisville @ Oklahoma City | 0–0 | Draw | 2021-08-22 | 0 |
| 35 | Oakland @ Las Vegas | 3–1 | Oakland win | 2021-08-22 | 0 |
| 35 | Orange County @ San Diego | 2–1 | Orange County win | 2021-08-22 | 0 |
| 35 | Rio Grande Valley @ El Paso | 1–3 | El Paso win | 2021-08-22 | 0 |
| 35 | Sacramento @ Phoenix | 0–0 | Draw | 2021-08-22 | 0 |
| 35 | Tulsa @ Birmingham | 2–1 | Tulsa win | 2021-08-22 | 0 |
| 35 | New Mexico @ Austin | 1–1 | Draw | 2021-08-24 | 0 |
| 35 | Real Monarchs @ San Antonio | 2–3 | San Antonio win | 2021-09-02 | 0 |
| Week 36 | |||||
| 36 | Tampa Bay @ Loudoun | 2–0 | Tampa Bay win | 2021-08-23 | 0 |
| 36 | Memphis @ Tulsa | 1–2 | Tulsa win | 2021-08-26 | 0 |
| Week 37 | |||||
| 37 | Charlotte @ Tampa Bay | 0–2 | Tampa Bay win | 2021-08-28 | 0 |
| 37 | Louisville @ Birmingham | 1–2 | Birmingham win | 2021-08-28 | 0 |
| 37 | Orange County @ Charleston | 0–0 | Draw | 2021-08-28 | 0 |
| 37 | Pittsburgh @ Hartford | 3–2 | Pittsburgh win | 2021-08-28 | 0 |
| 37 | Real Monarchs @ Indy | 0–2 | Indy win | 2021-08-28 | 0 |
| 37 | Ventura County @ Las Vegas | 3–2 | Ventura County win | 2021-08-28 | 0 |
| 37 | Atlanta @ Tulsa | 1–3 | Tulsa win | 2021-08-29 | 0 |
| 37 | Austin @ Colorado Springs | 1–4 | Colorado Springs win | 2021-08-29 | 0 |
| 37 | El Paso @ San Antonio | 1–2 | San Antonio win | 2021-08-29 | 0 |
| 37 | Memphis @ Kansas City | 0–0 | Draw | 2021-08-29 | 0 |
| 37 | New Mexico @ Phoenix | 2–3 | Phoenix win | 2021-08-29 | 0 |
| 37 | New York @ Miami | 0–3 | Miami win | 2021-08-29 | 0 |
| 37 | Rio Grande Valley @ Oklahoma City | 1–2 | Oklahoma City win | 2021-08-29 | 0 |
| 37 | San Diego @ Sacramento | 3–1 | San Diego win | 2021-08-29 | 0 |
| 37 | Tacoma @ Oakland | 1–3 | Oakland win | 2021-08-29 | 0 |
| Week 38 | |||||
| 38 | New York @ Pittsburgh | 0–1 | Pittsburgh win | 2021-09-01 | 0 |
| 38 | Oklahoma City @ Memphis | 1–0 | Oklahoma City win | 2021-09-02 | 0 |
| 38 | Sacramento @ Ventura County | 3–3 | Draw | 2021-09-02 | 0 |
| 38 | Las Vegas @ Tacoma | 1–2 | Tacoma win | 2021-09-03 | 0 |
| 38 | Charleston @ Hartford | 0–2 | Hartford win | 2021-10-26 | 0 |
| Week 39 | |||||
| 39 | Oakland @ Tampa Bay | 0–3 | Tampa Bay win | 2021-09-03 | 0 |
| 39 | Tulsa @ Louisville | 1–0 | Tulsa win | 2021-09-03 | 0 |
| 39 | Atlanta @ Indy | 1–0 | Atlanta win | 2021-09-04 | 0 |
| 39 | El Paso @ Orange County | 2–2 | Draw | 2021-09-04 | 0 |
| 39 | Hartford @ New York | 0–2 | New York win | 2021-09-04 | 0 |
| 39 | Miami @ Charlotte | 2–2 | Draw | 2021-09-04 | 0 |
| 39 | Oklahoma City @ Kansas City | 0–3 | Kansas City win | 2021-09-04 | 0 |
| 39 | Birmingham @ Memphis | 2–3 | Memphis win | 2021-09-05 | 0 |
| 39 | Colorado Springs @ New Mexico | 2–3 | New Mexico win | 2021-09-05 | 0 |
| 39 | Loudoun @ Rio Grande Valley | 1–1 | Draw | 2021-09-05 | 0 |
| 39 | Phoenix @ Tacoma | 3–1 | Phoenix win | 2021-09-05 | 0 |
| 39 | Pittsburgh @ San Antonio | 1–1 | Draw | 2021-09-05 | 0 |
| 39 | Ventura County @ San Diego | 2–4 | San Diego win | 2021-09-05 | 0 |
| 39 | Sacramento @ Las Vegas | 3–1 | Sacramento win | 2021-09-06 | 0 |
| Week 40 | |||||
| 40 | Louisville @ Hartford | 4–2 | Louisville win | 2021-09-07 | 0 |
| 40 | Tampa Bay @ Charleston | 1–0 | Tampa Bay win | 2021-09-07 | 0 |
| 40 | Charlotte @ Loudoun | 5–0 | Charlotte win | 2021-09-08 | 0 |
| 40 | San Antonio @ Austin | 1–2 | Austin win | 2021-09-08 | 0 |
| 40 | Indy @ Tulsa | 1–2 | Tulsa win | 2021-09-09 | 0 |
| 40 | Oakland @ Las Vegas | 1–0 | Oakland win | 2021-09-09 | 0 |
| 40 | Real Monarchs @ Colorado Springs | 0–2 | Colorado Springs win | 2021-09-09 | 0 |
| Week 41 | |||||
| 41 | Hartford @ Charlotte | 0–2 | Charlotte win | 2021-09-11 | 0 |
| 41 | Loudoun @ Pittsburgh | 0–5 | Pittsburgh win | 2021-09-11 | 0 |
| 41 | New Mexico @ Austin | 0–1 | Austin win | 2021-09-11 | 0 |
| 41 | New York @ Tampa Bay | 0–6 | Tampa Bay win | 2021-09-11 | 0 |
| 41 | Kansas City @ Indy | 0–1 | Indy win | 2021-09-11 | 0 |
| 41 | Birmingham @ Tulsa | 1–1 | Draw | 2021-09-12 | 0 |
| 41 | Louisville @ Oklahoma City | 1–1 | Draw | 2021-09-12 | 0 |
| 41 | Las Vegas @ Orange County | 0–3 | Orange County win | 2021-09-12 | 0 |
| 41 | Miami @ Memphis | 2–0 | Miami win | 2021-09-12 | 0 |
| 41 | Phoenix @ Ventura County | 4–3 | Phoenix win | 2021-09-12 | 0 |
| 41 | Rio Grande Valley @ Colorado Springs | 1–1 | Draw | 2021-09-12 | 0 |
| 41 | San Antonio @ Real Monarchs | 1–0 | San Antonio win | 2021-09-12 | 0 |
| 41 | Sacramento @ El Paso | 0–2 | El Paso win | 2021-09-12 | 0 |
| 41 | San Diego @ Oakland | 1–2 | Oakland win | 2021-09-23 | 0 |
| Week 42 | |||||
| 42 | Charleston @ Atlanta | 1–1 | Draw | 2021-09-15 | 0 |
| 42 | El Paso @ Colorado Springs | 0–0 | Draw | 2021-09-16 | 0 |
| 42 | Las Vegas @ Phoenix | 1–4 | Phoenix win | 2021-09-16 | 0 |
| Week 43 | |||||
| 43 | Louisville @ Indy | 2–0 | Louisville win | 2021-09-18 | 0 |
| 43 | Oklahoma City @ Birmingham | 1–1 | Draw | 2021-09-18 | 0 |
| 43 | Pittsburgh @ Charlotte | 0–1 | Charlotte win | 2021-09-18 | 0 |
| 43 | Tampa Bay @ Atlanta | 2–0 | Tampa Bay win | 2021-09-18 | 0 |
| 43 | Austin @ Tulsa | 1–0 | Austin win | 2021-09-19 | 0 |
| 43 | Charleston @ Miami | 1–1 | Draw | 2021-09-19 | 0 |
| 43 | Colorado Springs @ Rio Grande Valley | 2–1 | Colorado Springs win | 2021-09-19 | 0 |
| 43 | Memphis @ New York | 3–0 | Memphis win | 2021-09-19 | 0 |
| 43 | Orange County @ Phoenix | 1–2 | Phoenix win | 2021-09-19 | 0 |
| 43 | San Antonio @ Sacramento | 1–0 | San Antonio win | 2021-09-19 | 0 |
| 43 | Real Monarchs @ New Mexico | 1–2 | New Mexico win | 2021-09-19 | 0 |
| 43 | Tacoma @ San Diego | 0–1 | San Diego win | 2021-09-19 | 0 |
| 43 | Ventura County @ Oakland | 1–0 | Ventura County win | 2021-09-19 | 0 |
| 43 | Hartford @ Loudoun | 3–2 | Hartford win | 2021-10-13 | 0 |
| Week 44 | |||||
| 44 | San Diego @ Oakland | 0–0 | Draw | 2021-09-12 | 0 |
| 44 | Birmingham @ Atlanta | 4–0 | Birmingham win | 2021-09-22 | 0 |
| 44 | Miami @ Charlotte | 0–2 | Charlotte win | 2021-09-22 | 0 |
| 44 | El Paso @ Austin | 2–2 | Draw | 2021-09-23 | 0 |
| 44 | Indy @ Memphis | 0–1 | Memphis win | 2021-09-23 | 0 |
| 44 | Sacramento @ Tacoma | 1–0 | Sacramento win | 2021-09-23 | 0 |
| 44 | Rio Grande Valley @ New Mexico | 0–2 | New Mexico win | 2021-09-30 | 0 |
| Week 45 | |||||
| 45 | Charleston @ Pittsburgh | 3–3 | Draw | 2021-09-25 | 0 |
| 45 | Loudoun @ Miami | 1–6 | Miami win | 2021-09-25 | 0 |
| 45 | Tampa Bay @ Hartford | 2–1 | Tampa Bay win | 2021-09-25 | 0 |
| 45 | Tulsa @ Kansas City | 1–1 | Draw | 2021-09-25 | 0 |
| 45 | Atlanta @ Rio Grande Valley | 2–3 | Rio Grande Valley win | 2021-09-26 | 0 |
| 45 | Austin @ Colorado Springs | 1–3 | Colorado Springs win | 2021-09-26 | 0 |
| 45 | Charlotte @ Birmingham | 1–2 | Birmingham win | 2021-09-26 | 0 |
| 45 | Indy @ Oklahoma City | 0–2 | Oklahoma City win | 2021-09-26 | 0 |
| 45 | Louisville @ Memphis | 1–1 | Draw | 2021-09-26 | 0 |
| 45 | New Mexico @ San Antonio | 1–0 | New Mexico win | 2021-09-26 | 0 |
| 45 | Oakland @ Orange County | 1–2 | Orange County win | 2021-09-26 | 0 |
| 45 | Phoenix @ Tacoma | 2–1 | Phoenix win | 2021-09-26 | 0 |
| 45 | San Diego @ Las Vegas | 4–2 | San Diego win | 2021-09-26 | 0 |
| 45 | Ventura County @ Sacramento | 2–0 | Ventura County win | 2021-09-26 | 0 |
| 45 | New York @ Real Monarchs | 0–0 | Draw | 2021-09-27 | 0 |
| Week 46 | |||||
| 46 | Louisville @ Atlanta | 1–1 | Draw | 2021-09-29 | 0 |
| 46 | Loudoun @ New York | 3–3 | Draw | 2021-09-30 | 0 |
| 46 | Phoenix @ Ventura County | 0–3 | Ventura County win | 2021-09-30 | 0 |
| 46 | Real Monarchs @ El Paso | 0–1 | El Paso win | 2021-09-30 | 0 |
| 46 | Charlotte @ Hartford | 2–1 | Charlotte win | 2021-10-01 | 0 |
| 46 | Las Vegas @ Tacoma | 1–0 | Las Vegas win | 2021-10-14 | 0 |
| Week 47 | |||||
| 47 | Atlanta @ Indy | 1–1 | Draw | 2021-10-02 | 0 |
| 47 | Birmingham @ Kansas City | 1–0 | Birmingham win | 2021-10-02 | 0 |
| 47 | Pittsburgh @ Miami | 2–3 | Miami win | 2021-10-02 | 0 |
| 47 | Tampa Bay @ Charleston | 2–1 | Tampa Bay win | 2021-10-02 | 0 |
| 47 | El Paso @ Colorado Springs | 1–1 | Draw | 2021-10-03 | 0 |
| 47 | Loudoun @ Charlotte | 1–5 | Charlotte win | 2021-10-03 | 0 |
| 47 | Las Vegas @ Oakland | 2–2 | Draw | 2021-10-03 | 0 |
| 47 | Memphis @ Tulsa | 3–0 | Memphis win | 2021-10-03 | 0 |
| 47 | New Mexico @ Louisville | 1–3 | Louisville win | 2021-10-03 | 0 |
| 47 | Phoenix @ Orange County | 1–0 | Phoenix win | 2021-10-03 | 0 |
| 47 | San Antonio @ Oklahoma City | 1–0 | San Antonio win | 2021-10-03 | 0 |
| 47 | San Diego @ Ventura County | 3–0 | San Diego win | 2021-10-03 | 0 |
| 47 | Real Monarchs @ Rio Grande Valley | 0–3 | Rio Grande Valley win | 2021-10-03 | 0 |
| 47 | Tacoma @ Sacramento | 1–3 | Sacramento win | 2021-10-03 | 0 |
| Week 48 | |||||
| 48 | Hartford @ New Mexico | 2–2 | Draw | 2021-10-07 | 0 |
| 48 | San Antonio @ El Paso | 3–3 | Draw | 2021-10-07 | 0 |
| 48 | Sacramento @ Oakland | 1–2 | Oakland win | 2021-10-07 | 0 |
| 48 | Kansas City @ Memphis | 1–3 | Memphis win | 2021-10-07 | 0 |
| 48 | Charleston @ Tampa Bay | 2–4 | Tampa Bay win | 2021-10-08 | 0 |
| Week 49 | |||||
| 49 | Charlotte @ New York | 3–2 | Charlotte win | 2021-08-10 | 0 |
| 49 | Colorado Springs @ Real Monarchs | 0–0 | Draw | 2021-10-09 | 0 |
| 49 | Rio Grande Valley @ New Mexico | 1–1 | Draw | 2021-10-09 | 0 |
| 49 | Kansas City @ Louisville | 3–4 | Louisville win | 2021-10-09 | 0 |
| 49 | Ventura County @ Las Vegas | 1–0 | Ventura County win | 2021-10-09 | 0 |
| 49 | El Paso @ Tulsa | 2–1 | El Paso win | 2021-10-10 | 0 |
| 49 | Hartford @ Charleston | 3–4 | Charleston win | 2021-10-10 | 0 |
| 49 | Indy @ Birmingham | 1–3 | Birmingham win | 2021-10-10 | 0 |
| 49 | Miami @ Loudoun | 2–3 | Loudoun win | 2021-10-10 | 0 |
| 49 | Oakland @ Phoenix | 0–1 | Phoenix win | 2021-10-10 | 0 |
| 49 | Orange County @ Tacoma | 1–4 | Tacoma win | 2021-10-10 | 0 |
| 49 | Sacramento @ San Diego | 1–2 | San Diego win | 2021-10-10 | 0 |
| 49 | Tampa Bay @ Pittsburgh | 0–2 | Pittsburgh win | 2021-10-10 | 0 |
| 49 | Memphis @ San Antonio | 2–4 | San Antonio win | 2021-10-11 | 0 |
| 49 | Oklahoma City @ Austin | 1–1 | Draw | 2021-10-11 | 0 |
| Week 50 | |||||
| 50 | Atlanta @ Kansas City | 0–1 | Kansas City win | 2021-10-14 | 0 |
| 50 | Colorado Springs @ El Paso | 2–4 | El Paso win | 2021-10-14 | 0 |
| 50 | Louisville @ Memphis | 1–2 | Memphis win | 2021-10-14 | 0 |
| 50 | Phoenix @ Orange County | 0–1 | Orange County win | 2021-10-14 | 0 |
| 50 | Ventura County @ Sacramento | 1–1 | Draw | 2021-10-14 | 0 |
| Week 51 | |||||
| 51 | New York @ Tampa Bay | 1–1 | Draw | 2021-10-15 | 0 |
| 51 | Atlanta @ Memphis | 2–4 | Memphis win | 2021-10-16 | 0 |
| 51 | Austin @ Real Monarchs | 3–4 | Real Monarchs win | 2021-10-16 | 0 |
| 51 | Charleston @ Charlotte | 1–5 | Charlotte win | 2021-10-16 | 0 |
| 51 | Loudoun @ Hartford | 0–1 | Hartford win | 2021-10-16 | 0 |
| 51 | Louisville @ Indy | 0–1 | Indy win | 2021-10-16 | 0 |
| 51 | Phoenix @ Las Vegas | 6–3 | Phoenix win | 2021-10-16 | 0 |
| 51 | Birmingham @ Oklahoma City | 0–0 | Draw | 2021-10-17 | 0 |
| 51 | New Mexico @ San Diego | 1–1 | Draw | 2021-10-17 | 0 |
| 51 | Orange County @ Oakland | 1–0 | Orange County win | 2021-10-17 | 0 |
| 51 | Rio Grande Valley @ Colorado Springs | 0–1 | Colorado Springs win | 2021-10-17 | 0 |
| 51 | Tacoma @ Sacramento | 0–0 | Draw | 2021-10-17 | 0 |
| 51 | Tulsa @ San Antonio | 1–1 | Draw | 2021-10-17 | 0 |
| 51 | El Paso @ Ventura County | 0–5 | Ventura County win | 2021-10-18 | 0 |
| 51 | Pittsburgh @ Miami | 1–0 | Pittsburgh win | 2021-10-27 | 0 |
| Week 52 | |||||
| 52 | Loudoun @ New York | 0–3 | New York win | 2021-10-20 | 0 |
| 52 | Miami @ Tampa Bay | 0–3 | Tampa Bay win | 2021-10-20 | 0 |
| 52 | Atlanta @ Tulsa | 0–4 | Tulsa win | 2021-10-21 | 0 |
| 52 | Austin @ El Paso | 0–3 | El Paso win | 2021-10-21 | 0 |
| 52 | Oakland @ Tacoma | 0–0 | Draw | 2021-10-21 | 0 |
| 52 | San Antonio @ New Mexico | 2–4 | New Mexico win | 2021-10-21 | 0 |
| 52 | San Diego @ Orange County | 0–1 | Orange County win | 2021-10-21 | 0 |
| Week 53 | |||||
| 53 | Charlotte @ Hartford | 2–1 | Charlotte win | 2021-10-22 | 0 |
| 53 | Charleston @ Pittsburgh | 1–2 | Pittsburgh win | 2021-10-23 | 0 |
| 53 | Colorado Springs @ Real Monarchs | 1–1 | Draw | 2021-10-23 | 0 |
| 53 | Memphis @ Louisville | 1–3 | Louisville win | 2021-10-23 | 0 |
| 53 | Tampa Bay @ Loudoun | 1–0 | Tampa Bay win | 2021-10-23 | 0 |
| 53 | Tulsa @ Indy | 1–1 | Draw | 2021-10-23 | 0 |
| 53 | Austin @ San Antonio | 0–0 | Draw | 2021-10-24 | 0 |
| 53 | Las Vegas @ Orange County | 1–2 | Orange County win | 2021-10-24 | 0 |
| 53 | New Mexico @ Rio Grande Valley | 0–2 | Rio Grande Valley win | 2021-10-24 | 0 |
| 53 | New York @ Miami | 0–2 | Miami win | 2021-10-24 | 0 |
| 53 | Oakland @ San Diego | 4–3 | Oakland win | 2021-10-24 | 0 |
| 53 | Sacramento @ Phoenix | 1–1 | Draw | 2021-10-24 | 0 |
| 53 | Kansas City @ Birmingham | 0–6 | Birmingham win | 2021-10-24 | 0 |
| 53 | Ventura County @ Tacoma | 2–3 | Tacoma win | 2021-10-24 | 0 |
| 53 | Oklahoma City @ El Paso | 0–4 | El Paso win | 2021-10-25 | 0 |
| Week 54 | |||||
| 54 | Loudoun @ Charlotte | 0–1 | Charlotte win | 2021-10-27 | 0 |
| 54 | Rio Grande Valley @ Real Monarchs | 3–1 | Rio Grande Valley win | 2021-10-28 | 0 |
| 54 | Tulsa @ Memphis | 2–3 | Memphis win | 2021-10-28 | 0 |
| Week 55 | |||||
| 55 | Hartford @ Pittsburgh | 0–0 | Draw | 2021-10-30 | 0 |
| 55 | Indy @ Memphis | 0–3 | Memphis win | 2021-10-30 | 0 |
| 55 | Louisville @ Birmingham | 1–0 | Louisville win | 2021-10-30 | 0 |
| 55 | Miami @ Charleston | 4–0 | Miami win | 2021-10-30 | 0 |
| 55 | New York @ Loudoun | 4–1 | New York win | 2021-10-30 | 0 |
| 55 | Real Monarchs @ New Mexico | 1–3 | New Mexico win | 2021-10-30 | 0 |
| 55 | Charlotte @ Austin | 1–1 | Draw | 2021-10-31 | 0 |
| 55 | Colorado Springs @ San Antonio | 0–3 | San Antonio win | 2021-10-31 | 0 |
| 55 | El Paso @ Rio Grande Valley | 1–4 | Rio Grande Valley win | 2021-10-31 | 0 |
| 55 | Orange County @ Ventura County | 1–0 | Orange County win | 2021-10-31 | 0 |
| 55 | Oklahoma City @ Tulsa | 0–2 | Tulsa win | 2021-10-31 | 0 |
| 55 | San Diego @ Sacramento | 1–1 | Draw | 2021-10-31 | 0 |
| 55 | Kansas City @ Oakland | 0–1 | Oakland win | 2021-10-31 | 0 |
| 55 | Tacoma @ Phoenix | 1–1 | Draw | 2021-10-31 | 0 |
| 55 | Tampa Bay @ Las Vegas | 2–1 | Tampa Bay win | 2021-10-31 | 0 |
| Week 56 | |||||
| 56 | Memphis @ Charlotte | 1–3 | Charlotte win | 2021-11-06 | 0 |
| 56 | Oakland @ El Paso | 1–0 | Oakland win | 2021-11-06 | 0 |
| 56 | San Diego @ San Antonio | 0–2 | San Antonio win | 2021-11-06 | 0 |
| 56 | Tulsa @ Tampa Bay | 2–6 | Tampa Bay win | 2021-11-06 | 0 |
| 56 | Colorado Springs @ Orange County | 0–1 | Orange County win | 2021-11-07 | 0 |
| 56 | Miami @ Louisville | 0–1 | Louisville win | 2021-11-07 | 0 |
| 56 | Rio Grande Valley @ Phoenix | 3–3 | Draw | 2021-11-07 | 0 |
| Week 57 | |||||
| 57 | Birmingham @ Tampa Bay | 0–1 | Tampa Bay win | 2021-11-14 | 0 |
| 57 | Charlotte @ Louisville | 0–1 | Louisville win | 2021-11-14 | 0 |
| 57 | Oakland @ Orange County | 0–0 | Draw | 2021-11-14 | 0 |
| 57 | Rio Grande Valley @ San Antonio | 1–3 | San Antonio win | 2021-11-14 | 0 |